!!This displayer contains script commands. You should enable JavaScripting within your browser preferences, or use another browser!
USC-OGP 2-DE database
Two-dimensional polyacrylamide gel electrophoresis database
USC-OGP 2-DE database
Search by
Maps
Select Remote Interfaces
[All Interfaces]
SWISS-2DPAGE
World-2DPAGE Portal
World-2DPAGE Repository
Exclude local DBs
has only effect if a remote
interface is selected
Searching in 'USC-OGP 2-DE database' for entry
matching:
P08238
USC-OGP 2-DE database
:
P08238
P08238
General information about the entry
View entry in simple text format
Entry name
HS90B_HUMAN
Primary accession number
P08238
integrated into USC-OGP 2-DE database on
January 17, 2017 (release 1)
2D Annotations were last modified on
January 17, 2017 (version 1)
General Annotations were last modified on
April 5, 2017 (version 2)
Name and origin of the protein
Description
RecName: Full=Heat shock protein HSP 90-beta; Short=HSP 90; AltName: Full=Heat shock 84 kDa; Short=HSP 84; Short=HSP84;.
Gene name
Name=HSP90AB1
Synonyms=HSP90B, HSPC2, HSPCB
Annotated species
Homo sapiens (Human) [TaxID:
9606
]
Taxonomy
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]
2D GEL CHARACTERIZATION
Author 1., Author 2.
Submitted (Mar-2011) to Current
2D PAGE maps for identified proteins
How to interpret a protein
PLATELET_4-5
{PLATELET 4-5}
Homo sapiens (Human)
map experimental info
PLATELET_4-5
MAP LOCATIONS:
SPOT OGP-0046
:
pI=4.80; Mw=56520
UVEAL_MELANOMA_3-10
{UVEAL MELANOMA 3-10}
Homo sapiens (Human)
map experimental info
UVEAL_MELANOMA_3-10
MAP LOCATIONS:
SPOT OGP-1111
:
pI=5.20; Mw=104418
Cross-references
UniProtKB/Swiss-Prot
P08238; HS90B_HUMAN.
2D PAGE maps for identified proteins
How to interpret a protein map
You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
Warning 1
: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
Warning 2
: the 2D PAGE map is built on demand. This may take some few seconds to be computed.
External data extracted from
UniProtKB/Swiss-Prot
Extracted from
UniProtKB/Swiss-Prot
, release:
0.0
Entry name
HS90B_HUMAN
Primary accession number
P08238
Secondary accession number(s)
B2R5P0 Q5T9W7 Q9NQW0 Q9NTK6
Sequence was last modified on
January 23, 2007 (version 4)
Annotations were last modified on
March 15, 2017 (version 218)
Name and origin of the protein
Description
RecName: Full=Heat shock protein HSP 90-beta; Short=HSP 90; AltName: Full=Heat shock 84 kDa; Short=HSP 84; Short=HSP84;
Gene name
Name=HSP90AB1
Synonyms=HSP90B, HSPC2, HSPCB
Encoded on
Name=HSP90AB1; Synonyms=HSP90B, HSPC2, HSPCB
Keywords
3D-structure
;
Acetylation
;
ATP-binding
;
Chaperone
;
Complete proteome
;
Cytoplasm
;
Direct protein sequencing
;
Glycoprotein
;
Nucleotide-binding
;
Phosphoprotein
;
Polymorphism
;
Reference proteome
;
S-nitrosylation
;
Stress response
;
Ubl conjugation
.
Copyright
Copyrighted by the UniProt Consortium, see
http://www.uniprot.org/help/license
. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBL
M16660; AAA36025.1
; -; mRNA
EMBL
J04988; AAA36026.1
; -; Genomic_DNA
EMBL
AY359878; AAQ63401.1
; -; mRNA
EMBL
AL136543; CAB66478.1
; ALT_FRAME; mRNA
EMBL
AK312255; BAG35187.1
; -; mRNA
EMBL
DQ314872; ABC40731.1
; -; Genomic_DNA
EMBL
AL139392; CAI20095.1
; -; Genomic_DNA
EMBL
CH471081; EAX04257.1
; -; Genomic_DNA
EMBL
BC004928; AAH04928.1
; -; mRNA
EMBL
BC009206; AAH09206.2
; -; mRNA
EMBL
BC012807; AAH12807.1
; -; mRNA
EMBL
BC014485; AAH14485.1
; -; mRNA
EMBL
BC016753; AAH16753.1
; -; mRNA
EMBL
BC068474; AAH68474.1
; -; mRNA
EMBL
AH007358; AAD14062.3
; ALT_INIT; Genomic_DNA
EMBL
AF275719; AAF82792.1
; -; mRNA
CCDS
CCDS4909.1; -
; .
PIR
A29461; HHHU84
; .
PIR
T46243; T46243
; .
RefSeq
NP_001258898.1; NM_001271969.1
; .
RefSeq
NP_001258899.1; NM_001271970.1
; .
RefSeq
NP_001258900.1; NM_001271971.1
; .
RefSeq
NP_031381.2; NM_007355.3
; .
UniGene
Hs.509736; -
; .
PDB
1QZ2; X-ray
; 3.00 A; G/H=720-724
PDB
1UYM; X-ray
; 2.45 A; A=2-221
PDB
2L6J; NMR
; -; B=720-724
PDB
3FWV; X-ray
; 2.20 A; C/D=719-723
PDB
3NMQ; X-ray
; 2.20 A; A=1-223
PDB
3PRY; X-ray
; 2.28 A; A/B/C=284-543
PDB
3UQ3; X-ray
; 2.60 A; B/C=720-724
PDB
5FWK; EM
; 3.90 A; A/B=1-724
PDB
5FWL; EM
; 9.00 A; A/B=1-724
PDB
5FWM; EM
; 8.00 A; A/B=1-724
PDB
5FWP; EM
; 7.20 A; A/B=1-724
PDBsum
1QZ2; -
; .
PDBsum
1UYM; -
; .
PDBsum
2L6J; -
; .
PDBsum
3FWV; -
; .
PDBsum
3NMQ; -
; .
PDBsum
3PRY; -
; .
PDBsum
3UQ3; -
; .
PDBsum
5FWK; -
; .
PDBsum
5FWL; -
; .
PDBsum
5FWM; -
; .
PDBsum
5FWP; -
; .
ProteinModelPortal
P08238; -
; .
SMR
P08238; -
; .
BioGrid
109558; 314
; .
DIP
DIP-413N; -
; .
IntAct
P08238; 522
; .
MINT
MINT-99712; -
; .
STRING
9606.ENSP00000325875; -
; .
BindingDB
P08238; -
; .
ChEMBL
CHEMBL4303; -
; .
DrugBank
DB05134; CNF1010
; .
DrugBank
DB02424; Geldanamycin
; .
DrugBank
DB03758; Radicicol
; .
DrugBank
DB06070; SNX-5422
; .
GuidetoPHARMACOLOGY
2907; -
; .
iPTMnet
P08238; -
; .
PhosphoSitePlus
P08238; -
; .
SwissPalm
P08238; -
; .
DMDM
17865718; -
; .
OGP
P08238; -
; .
EPD
P08238; -
; .
MaxQB
P08238; -
; .
PaxDb
P08238; -
; .
PeptideAtlas
P08238; -
; .
PRIDE
P08238; -
; .
TopDownProteomics
P08238; -
; .
DNASU
3326; -
; .
Ensembl
ENST00000353801; ENSP00000325875
; ENSG00000096384; .
Ensembl
ENST00000371554; ENSP00000360609
; ENSG00000096384; .
Ensembl
ENST00000371646; ENSP00000360709
; ENSG00000096384; .
Ensembl
ENST00000620073; ENSP00000481908
; ENSG00000096384; .
GeneID
3326; -
; .
KEGG
hsa:3326; -
; .
UCSC
uc003oxa.3; human
; .
CTD
3326; -
; .
DisGeNET
3326; -
; .
GeneCards
HSP90AB1; -
; .
H-InvDB
HIX0031498; -
; .
H-InvDB
HIX0057380; -
; .
HGNC
HGNC:5258; HSP90AB1
; .
HPA
CAB005230; -
; .
HPA
HPA055729; -
; .
MIM
140572; gene
; .
neXtProt
NX_P08238; -
; .
OpenTargets
ENSG00000096384; -
; .
PharmGKB
PA29524; -
; .
eggNOG
KOG0019; Eukaryota
; .
eggNOG
KOG0020; Eukaryota
; .
eggNOG
COG0326; LUCA
; .
GeneTree
ENSGT00840000129758; -
; .
HOGENOM
HOG000031988; -
; .
HOVERGEN
HBG007374; -
; .
InParanoid
P08238; -
; .
KO
K04079; -
; .
OMA
AFANDIC; -
; .
OrthoDB
EOG091G0270; -
; .
PhylomeDB
P08238; -
; .
TreeFam
TF300686; -
; .
Reactome
R-HSA-2029482; Regulation of actin dynamics for phagocytic cup formation
; .
Reactome
R-HSA-3371511; HSF1 activation
; .
Reactome
R-HSA-3371568; Attenuation phase
; .
Reactome
R-HSA-3371571; HSF1-dependent transactivation
; .
Reactome
R-HSA-399954; Sema3A PAK dependent Axon repulsion
; .
Reactome
R-HSA-5336415; Uptake and function of diphtheria toxin
; .
Reactome
R-HSA-6798695; Neutrophil degranulation
; .
Reactome
R-HSA-844456; The NLRP3 inflammasome
; .
Reactome
R-HSA-8852276; The role of GTSE1 in G2/M progression after G2 checkpoint
; .
Reactome
R-HSA-8937144; Aryl hydrocarbon receptor signalling
; .
SIGNOR
P08238; -
; .
ChiTaRS
HSP90AB1; human
; .
EvolutionaryTrace
P08238; -
; .
GeneWiki
HSP90AB1; -
; .
GenomeRNAi
3326; -
; .
PRO
PR:P08238; -
; .
Proteomes
UP000005640; Chromosome 6
; .
Bgee
ENSG00000096384; -
; .
CleanEx
HS_HSP90AB1; -
; .
ExpressionAtlas
P08238; baseline and differential
; .
Genevisible
P08238; HS
; .
GO
GO:0016324; C:apical plasma membrane
; IEA:Ensembl; .
GO
GO:0034751; C:aryl hydrocarbon receptor complex
; IDA:UniProtKB; .
GO
GO:0016323; C:basolateral plasma membrane
; IEA:Ensembl; .
GO
GO:0031526; C:brush border membrane
; IEA:Ensembl; .
GO
GO:0009986; C:cell surface
; IEA:Ensembl; .
GO
GO:0005737; C:cytoplasm
; IDA:UniProtKB; .
GO
GO:0005829; C:cytosol
; IDA:HPA; .
GO
GO:0070062; C:extracellular exosome
; IDA:UniProtKB; .
GO
GO:0005576; C:extracellular region
; TAS:Reactome; .
GO
GO:1904813; C:ficolin-1-rich granule lumen
; TAS:Reactome; .
GO
GO:0016234; C:inclusion body
; IEA:Ensembl; .
GO
GO:0005765; C:lysosomal membrane
; IEA:Ensembl; .
GO
GO:0042470; C:melanosome
; IEA:UniProtKB-SubCell; .
GO
GO:0016020; C:membrane
; IDA:UniProtKB; .
GO
GO:0005739; C:mitochondrion
; IDA:UniProtKB; .
GO
GO:0005654; C:nucleoplasm
; TAS:Reactome; .
GO
GO:0005634; C:nucleus
; IDA:UniProtKB; .
GO
GO:1990917; C:ooplasm
; IEA:Ensembl; .
GO
GO:0034774; C:secretory granule lumen
; TAS:Reactome; .
GO
GO:1990913; C:sperm head plasma membrane
; IEA:Ensembl; .
GO
GO:0005524; F:ATP binding
; IEA:UniProtKB-KW; .
GO
GO:0045296; F:cadherin binding
; IDA:BHF-UCL; .
GO
GO:0002135; F:CTP binding
; IEA:Ensembl; .
GO
GO:0032564; F:dATP binding
; IEA:Ensembl; .
GO
GO:0070182; F:DNA polymerase binding
; IPI:BHF-UCL; .
GO
GO:0003725; F:double-stranded RNA binding
; IDA:MGI; .
GO
GO:0008144; F:drug binding
; IEA:Ensembl; .
GO
GO:0005525; F:GTP binding
; IEA:Ensembl; .
GO
GO:0031072; F:heat shock protein binding
; IPI:UniProtKB; .
GO
GO:0042826; F:histone deacetylase binding
; IPI:BHF-UCL; .
GO
GO:1990226; F:histone methyltransferase binding
; IPI:UniProtKB; .
GO
GO:0019900; F:kinase binding
; IPI:UniProtKB; .
GO
GO:0023026; F:MHC class II protein complex binding
; IDA:UniProtKB; .
GO
GO:0030235; F:nitric-oxide synthase regulator activity
; ISS:UniProtKB; .
GO
GO:0046983; F:protein dimerization activity
; IDA:UniProtKB; .
GO
GO:0019887; F:protein kinase regulator activity
; IEA:Ensembl; .
GO
GO:0003723; F:RNA binding
; IDA:UniProtKB; .
GO
GO:0030911; F:TPR domain binding
; ISS:UniProtKB; .
GO
GO:0002134; F:UTP binding
; IEA:Ensembl; .
GO
GO:0035690; P:cellular response to drug
; IEA:Ensembl; .
GO
GO:0071353; P:cellular response to interleukin-4
; IEA:Ensembl; .
GO
GO:0071407; P:cellular response to organic cyclic compound
; IEA:Ensembl; .
GO
GO:0038096; P:Fc-gamma receptor signaling pathway involved in phagocytosis
; TAS:Reactome; .
GO
GO:1903660; P:negative regulation of complement-dependent cytotoxicity
; IEA:Ensembl; .
GO
GO:0043524; P:negative regulation of neuron apoptotic process
; IEA:Ensembl; .
GO
GO:0032435; P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process
; IDA:UniProtKB; .
GO
GO:0043312; P:neutrophil degranulation
; TAS:Reactome; .
GO
GO:0001890; P:placenta development
; IEA:Ensembl; .
GO
GO:0045597; P:positive regulation of cell differentiation
; IMP:UniProtKB; .
GO
GO:0045793; P:positive regulation of cell size
; IEA:Ensembl; .
GO
GO:0045429; P:positive regulation of nitric oxide biosynthetic process
; ISS:UniProtKB; .
GO
GO:0032516; P:positive regulation of phosphoprotein phosphatase activity
; IDA:UniProtKB; .
GO
GO:0032092; P:positive regulation of protein binding
; IEA:Ensembl; .
GO
GO:0033160; P:positive regulation of protein import into nucleus
; translocation; IEA:Ensembl
GO
GO:2000010; P:positive regulation of protein localization to cell surface
; IDA:UniProtKB; .
GO
GO:0071902; P:positive regulation of protein serine/threonine kinase activity
; IEA:Ensembl; .
GO
GO:0051973; P:positive regulation of telomerase activity
; IDA:BHF-UCL; .
GO
GO:0030511; P:positive regulation of transforming growth factor beta receptor signaling pathway
; IDA:UniProtKB; .
GO
GO:0006457; P:protein folding
; IEA:InterPro; .
GO
GO:0050821; P:protein stabilization
; TAS:Reactome; .
GO
GO:1900034; P:regulation of cellular response to heat
; TAS:Reactome; .
GO
GO:0060334; P:regulation of interferon-gamma-mediated signaling pathway
; IMP:MGI; .
GO
GO:0031396; P:regulation of protein ubiquitination
; IDA:BHF-UCL; .
GO
GO:0060338; P:regulation of type I interferon-mediated signaling pathway
; IMP:MGI; .
GO
GO:0042220; P:response to cocaine
; IEA:Ensembl; .
GO
GO:0009651; P:response to salt stress
; IEA:Ensembl; .
GO
GO:0006986; P:response to unfolded protein
; NAS:UniProtKB; .
GO
GO:0097435; P:supramolecular fiber organization
; IMP:CACAO; .
GO
GO:1905323; P:telomerase holoenzyme complex assembly
; IDA:BHF-UCL; .
GO
GO:0007004; P:telomere maintenance via telomerase
; IDA:BHF-UCL; .
GO
GO:0019062; P:virion attachment to host cell
; IMP:CACAO; .
GO
GO:0006805; P:xenobiotic metabolic process
; TAS:Reactome; .
Gene3D
3.30.565.10; -
; 2; .
HAMAP
MF_00505; HSP90
; 1; .
InterPro
IPR003594; HATPase_C
; .
InterPro
IPR019805; Heat_shock_protein_90_CS
; .
InterPro
IPR001404; Hsp90_fam
; .
InterPro
IPR020575; Hsp90_N
; .
InterPro
IPR020568; Ribosomal_S5_D2-typ_fold
; .
PANTHER
PTHR11528; PTHR11528
; 1; .
Pfam
PF02518; HATPase_c
; 1; .
Pfam
PF00183; HSP90
; 1; .
PIRSF
PIRSF002583; Hsp90
; 1; .
PRINTS
PR00775; HEATSHOCK90
; .
SMART
SM00387; HATPase_c
; 1; .
SUPFAM
SSF54211; SSF54211
; 1; .
SUPFAM
SSF55874; SSF55874
; 1; .
PROSITE
PS00298; HSP90
; 1; .
Gateways to other related servers
The World-2DPAGE Constellation
- Entry point to the world-wide 2-DPAGE resources.
World-2DPAGE Repository
- A public repository for gel-based proteomics data linked to protein identification published in the literature.
World-2DPAGE Portal
- A dynamic portal to query simultaneously world-wide gel-based proteomics databases.
SWISS-2DPAGE
- The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
ExPASy
- The resources web server of the
Swiss Institute of Bioinformatics
Database constructed and maintained by
Angel Garcia
, using the
Make2D-DB II
package (
ver. 3.10.2
) from the
World-2DPAGE Constellation
of the
ExPASy web server
[
Home
]